左坚 博士

皖南医学院/弋矶山医院

合作时间

      2018 ~ 今

合作项目

左坚, 李艳, 董继扬等. 基于 NAMPT/SIRT1 对脂代谢的调控作用研究清络饮从湿论治热痹的原理(81973828). 国家自然科学基金. 2020.01~2023.12.

合作成果

Jian Zuo#, Meng-Qing Tao#, Xin-Yue Wu, Tian-Tian Jiang, Opeyemi Joshua Olatunji, Jiyang Dong, Jun Han*, Cong-Lan Ji*. Securidaca inappendiculata-Derived Xanthones Protected Joints from Degradation in Male Rats with Collagen-Induced Arthritis by Regulating PPAR-γ Signaling. Journal of Inflammation Research, 2021, 14: 395 – 411

Conglan Ji, Sheng Dai, Hong Liu, Jiyang Dong, Chunsheng Liu, Jian Zuo. Polyphenols from Securidaca inappendiculata alleviated acute lung injury in rats by inhibiting oxidative stress sensitive pathways. Chinese Herbal Medicines. 2021, DOI:10.1016/j.chmed.2020.09.007

Mengqing Tao, Cong-Lan Ji, Yijin Wu, Jiyang Dong, Opeyemi J Olatunji, Yan Li, Jian Zuo*. 1,7-Dihydroxy-3,4-Dimethoxyxanthone Inhibits Lipopolysaccharide-Induced Inflammation in RAW264.7 Macrophages by Suppressing TLR4/NF-κB Signaling Cascades. Inflammation. 2020. 43 (5):1821-1831

Jian Zuo, Cong-Lan Ji, Olatunji Opeyemi, Zhe Yang, Hui-Fang Xu, Jun Han*, Jiyang Dong*. Bioactive fractions from Securidaca inappendiculata alleviated collagen induced arthritis in rats by regulating metabolism related signaling. The Kaohsiung Journal of Medical Sciences. 2020, 36:523–534

Kui Yang, Qin Yin, Qingcheng Mao, Sheng Dai, LinWang, Jiyang Dong, Jian Zuo*. Metabolomics Analysis Reveals Therapeutic Effects of α-Mangostin on Collagen-Induced Arthritis in Rats by Down-regulating Nicotinamide Phosphoribosyltransferase. Inflammation. 2019, 42(2):741-753.

Mengqing Tao, Jia Jiang, Lin Wang, Yan Li, Qingcheng Mao, Jiyang Dong, Jian Zuo*. α-Mangostin Alleviated Lipopolysaccharide Induced Acute Lung Injury in Rats by Suppressing NAMPT/NAD Controlled Inflammatory Reactions. Evidence-based Complementary and Alternative Medicine. 2018, Article ID 5470187