许晶晶

职称：高级工程师、硕导

系别：电子科学系

Email：jingjing@xmu.edu.cn

联系方式：0592-2183301

办公地点：厦门大学翔安校区文宣楼

教育背景

厦门大学 无线电物理 博士 2005.9 – 2011.7

厦门大学 电子信息科学与技术 学士 2001.9 - 2005.7

主要研究方向

网络建模新方法及其在生物医学领域的应用研究

多组学数据融合        

主讲课程

研究生课程《文献检索及科技英文论文写作》 

学术兼职

福建省等离子体与磁共振研究重点实验室 行政秘书

成果奖励

《基于代谢组学的解毒化浊祛瘀法干预肝豆状核变性肝纤维化机制研究》安徽省中医药科学技术奖三等奖

课题项目

国家自然科学基金，面上项目，基于系统生物网络的代谢组学新方法及在矮小症研究中的应用，2021-01-2024-12，55万元，在研，参加（排名第二）

福建省自然科学基金，面上项目，基于代谢表型的网络分析新方法及其在腧穴配伍效应评价中的应用，2020-05-2023-05，5万元，在研，主持

国家自然科学基金青年项目，基于网络分析的代谢组学新方法及在结直肠癌研究中的应用  2019/01-2021/12，21万元(直接经费)，在研，参加（排名第二）

福建省自然科学基金，基于核磁共振代谢组学技术研究艾灸胃经穴治疗慢性萎缩性胃炎癌前病变的作用机制  2015/04-2018/04，已结题，主持

福建省社会发展引导性项目，核磁共振代谢轮廓分析新技术及在妊娠期糖尿病研究中的应用  2015/04-2018/03，已结题，参加（排名第三）

国家自然科学基金面上项目，基于核磁共振代谢组学技术研究电针胃经穴对胃黏膜损伤修复的脑胃响应机制  2015/01-2018/12，已结题，参加（排名第二）

国家自然科学基金面上项目，代谢组学数据融合与建模新方法及在糖尿病肾病中的应用  2014/01-2017/12，已结题，参加（排名第三）

国家自然科学基金青年基金，基于磁共振的代谢组成像新方法及其在活体组织中的应用  2013/01-2015/12，已结题，主持

国家自然科学基金面上项目，基于核磁共振的代谢组学技术发现胰腺癌的生物标志物及其早期诊断的应用  2013/01-2016/12，已结题，参加（排名第四）

代表作

[1]Jingjing Xu, Yuanshan Wang, Xiangnan Xu, Kian-Kai Cheng, Daniel Raftery, Jiyang Dong*, NMF-based approach for missing values imputation of mass spectrometry metabolomics data, Molecules, 2021, 26(19): 5787.

[2]Wuping Liu, Jingjing Xu, Tao Dai, Guiping Shen, Jianghua Feng*, An integrating strategy for serum metabolomics and microarray analysis to expand the understanding of diet-induced obesity, Analytical Methods, 2021, 13(28): 3127-3135.

[3]Lei Guo^#, Zhenxing Hu^#, Chao Zhao*, Xiangnan Xu, Shujuan Wang, Jingjing Xu, Jiyang Dong, Zongwei Cai*, Data filtering and its proioritization in pipelines for spatial segmentation of mass spectrometry imaging, Analytical chemistry, 2021, 93(11): 4788-4793.

[4]Lei Guo, Yongpei Wang, Xiangnan Xu, Kian-Kai Cheng, Yichi Long, Jingjing Xu, Sanshu Li, Jiyang Dong*, DeepPSP: A Global-Local Information-Based Deep Neural Network for the Prediction of Protein Phosphorylation Sites, Journal of Proteome Research, 2021, 20(1): 346-356.

[5]Jingjing Xu, Yijia Liu, Xiangnan Xu, Kian-Kai Cheng, Zongbao Yang, Jiyang Dong*, Selection of acupoints combination based on pseudo mutual information maximization, IEEE Access, 2020, 8: 153707-153718.

[6]Yueyue Liu, Xiangnan Xu, Lingli Deng, Kian-Kai Cheng, Jingjing Xu, Daniel Raftery, Jiyang Dong*, A novel network modelling for metabolite set analysis: A case study on CRC metabolomics, IEEE Access, 2020, 8: 106425-106436.

[7]Yu Bo, Jianghua Feng, Jingjing Xu, Yuqing Huang, Honghao Cai, Xiaohong Cui*, Jiyang Dong*, Shangwu Ding, Zhong Chen, High-resolution pure shift NMR spectroscopy offers better metabolite discrimination in food quality analysis, Food Research International, 2019, 125: 108574.

[8]Guiping Shen*, Shenghao Wang, Jiyang Dong, Jianghua Feng, Jingjing Xu, Feng Xia, Xuexi Wang, Jidan Ye*, Metabolic effect of dietary taurine supplementation on Grouper (Epinephelus coiides): A H-1-NMR-based metabolomics study, Molecules, 2019, 24(12): 2253

[9]Xianwei Lin, Xia Liu, Jingjing Xu, Kian-Kai Cheng, Jianan Cao, Tao Liu, Qiong Liu, Huan Zhong, Guiping Shen, Jiyang Dong*, Xiaorong Chang*, Metabolomics analysis of herb-partitioned moxibustion treatment on rats with diarrhea-predominant irritable bowel syndrome, Chinese Medicine, 2019, 14: 18

[10]Jingjing Xu, Xianwei Lin, Kian-Kai Cheng, Huan Zhong, Mi Liu, Guoshan Zhang, Guiping Shen, Jiyang Dong*, Metabolic Response in Rats following Electroacupuncture or Moxibustion Stimulation, Evidence-based Complementary Alternative Medicine, 2019, 6947471.

[11]Guiping Shen*, Yin Huang, Jiyang Dong, Xuexi Wang, Kian-Kai Cheng, Jianghua Feng, Jingjing Xu, Jidan Ye*, Metabolic effect of dietary taurine supplementation on Nile Tilapia (Oreochromis nilotictus) evaluated by NMR-based metabolomics, Journal of Agricultural and Food Chemistry, 2018, 66(1): 368-377.

[12]Jingjing Xu, Xujuan Zheng, Kian-Kai Cheng, Xiaorong Chang, Guiping Shen, Mi Liu, Yadong Wang, Jiacheng Shen, Qida He, Jiyang Dong*, Zongbao Yang*, NMR-based metabolomics reveals alteration of electro-acupuncture stimulation on chronic atrophic gastritis rats. Scientific Reports, 2017, 7: 45580.

[13]Weijun Meng, Xiangnan Xu, Kian-Kai Cheng, Jingjing Xu*, Guiping Shen, Zhidan Wu, Jiyang Dong*, Geographical origin discrimination of Oolong tea (TieGuanYin, Camellia sinensis (L.) O. Kuntze) using proton nuclear magnetic resonance spectroscopy and near-infrared spectroscopy. Food Analytical Method, 2017, 10(11): 3508-3522.

[14]Caigui Lin, Zhiliang Wei, Kian-Kai Cheng, Jingjing Xu, Guiping Shen, Chang She, Huan Zhong, Xiaorong Chang*, Jiyang Dong*, ¹H NMR-based investigated of metabolic response to electro-acupuncture stimulation. Scientific Reports, 2017, 7: 6820.

[15] Wanlan Wang, Kian-Kai Cheng, Lingli Deng, Jingjing Xu, Guiping Shen, Julian L. Griffin, Jiyang Dong*, A clustering-based preprocessing method for the elimination of unwanted residuals in metabolomic data, Metabolomics, 2017, 13(10): 1-11.

[16]Jingjing Xu, Huaizhou Jiang, Jinquan Li, Kian-Kai Cheng, Jiyang Dong*, Zhong Chen, ¹H NMR-based metabolomics investigation of copper-laden rat: a model of Wilson’s disease, PLoS One, 2015, 10: e0119654

[17]Jingjing Xu, Kian-Kai Cheng, Zongbao Yang*, Chao Wang, Guiping Shen, Yadong Wang, Qiong Liu, Jiyang Dong*, ¹H NMR metabolic profiling of biofulids from rats with gastric mucosal lesion and electroacupuncture treatment, Evidence-based Complementary Alternative Medicine, 2015, 801691.

[18]Zhishui Li, ChengHong Lin, Jingjing Xu, Huifeng Wu, JingHua Feng*, Heguang Huang. The relations between metabolic variations and genetic evolution of different species. Analytical Biochemistry, 2015, 477: 105-114

[19]杨宗保, 沈佳成, 王亚东, 刘彩春, 董继扬, 许晶晶*. 应用¹H NMR代谢组技术研究电针治疗胃溃疡的中枢响应机制, 中华中医药杂志, 2017, 32(7): 3191-3195.

[20]杨宗保, 王亚东, 董继扬, 刘琼, 王超, 马富强, 文磊, 全仁夫, 许晶晶*.电针胃经穴对胃溃疡模型大鼠血清和尿液代谢轮廓的影响, 中华中医药杂志, 2016, 31(10): 4180-4183.

[21]全仁夫*，胡华辉，黄小龙，刘飞，杨宗保，许晶晶。电针秩边穴和水道穴对急性脊髓不完全损伤大鼠脑皮质代谢物的影响，中医正骨，2016，28(11): 801-806.

[22]蒋怀周*，王键，许晶晶，董继扬。Wilson病铜过量负荷大鼠肝损伤的代谢组学研究，山西医科大学学报，2016，47(3): 199-204.

[23]刘晓莎, 董继扬, 孟维君, 吴志丹, 许晶晶*. 铁观音茶水浸出物的溶出规律及香型差异的核磁共振氢谱分析, 茶叶学报, 2015，56(4): 198-205.

[24]蒋怀周*，王键，许晶晶，董继扬。肝豆灵干预铜负荷大鼠肾损伤的代谢组学研究，云南中医学院学报，2015，38(6): 8-12.

[25]Jingjing Xu, Changqin Liu, Shuhui Cai, Jiyang Dong*, Xuejun Li, Jianghua Feng and Zhong Chen. Metabolomic profilings of urine and serum from high fat-fed rats via 1H NMR spectroscopy and pattern recognition. Applied Biochemistry and Biotechonology, 2013, 169: 1250-1261

[26]Jingjing Xu, Shuhui Cai, Xuejun Li, Jiyang Dong*, Jun Ding and Zhong Chen. Statistical two-dimensional correlation spectroscopy of urine and serum from metabolomics data. Chemometrics and Intelligent Laboratory Systems, 2012, 112: 33-40

[27]Dong Ouyang, Jingjing Xu, Heguang Huang* and Zhong Chen*. Metabolomic profiling of serum from human pancreatic cancer patients using 1H NMR spectroscopy and principal component analysis. Applied Biochemistry and Biotechnology, 2011, 165:148-154

[28]Jiyang Dong*, Kian-Kai Cheng, Jingjing Xu, Zhong Chen, Jules L. Griffin, Group aggregating normalization method for the preprocessing of NMR-based metabolomic data. Chemometrics and Intelligent Laboratory Systems, 2011, 108:123-132

[29] Jingjing Xu, Shuyu Yang, Shuhui Cai*, Jiyang Dong, Xuejun Li*, Zhong Chen, Identification of biochemical changes in lactovegetarian urine using 1H NMR spectroscopy and pattern recognition, Analytical and Bioanalytical Chemistry, 2010, 396: 1451-1463.