邓伶莉

职称：讲师/硕导

系别：东华理工大学信息工程学院

Email：lldeng@ecut.edu.cn

教育背景

厦门大学  通信与信息系统专业  博士     2009.09 – 2015.07

美国华盛顿大学  医学院  博士联合培养    2013.11 – 2014.11

大连海事大学  通信工程专业   学士       2005.09 - 2009.07

主要研究方向

生物信息学

机器学习

多组学数据分析

健康大数据的网络分析                                                                                                                                                

课题项目

1、个体化分子网络建模新方法应用于结直肠癌代谢异质性研究，国基自然科学基金（地区）项目，2024.1-2027.12, 在研，主持

2、基于网络分析的代谢组学新方法及在结直肠癌研究中的应用，国家自然科学基金（青年）项目， 2019.1-2021.12，已结题，主持

3、二维磁共振代谢组学新方法，江西省教育厅自然科学基金，2017.1-2019.12，已结题，主持

4、通过呼出气体实时监测肝衰竭的方法研究，国家自然科学基金（地区）项目，2017.1-2020.12，已结题，参与

5、基于核磁共振代谢组学技术研究点针胃经穴对胃黏膜损伤修复的脑胃相应机制，国家自然科学基金（面上）项目. 2015.01-2018.12，已结题，参与

6、代谢组学数据融合与建模新方法及在糖尿病肾病研究中的应用，国家自然科学基金（面上）项目，2014.01-2017.12，已结题，参与

代表作

[1] Genjin Lin, Liheng Dong, Kian-Kai Cheng, Xiangnan Xu, Yongpei Wang, Lingli Deng*, Daniel Raftery, Jiyang Dong*. Differential Correlations Informed Metabolite Set Enrichment Analysis to Decipher Metabolic Heterogeneity of Disease. Analytical Chemistry, 2023, 33: 12505-12513.

[2] Congcong Guo#, Jiyang Dong#, Lingli Deng, Kian-Kai Cheng, Yue Xu, Haowen Zhu, Anjun Deng, Qinhai Lin*, Yinghong Wang*. Application of bs-HSQC-NMR in Species identification and Adulteration behavior analysis of Panax Linn. Molecules, 2023, 28, 4332.

[3] Yongpei Wang#, Xingxing Liu#, Liheng Dong, Kian-Kai Cheng, Caigui Lin, Xiaomin Wang, Jiyang Dong*, Lingli Deng*, Daniel Raftery. iMSEA: A Novel Metabolite Set Enrichment Analysis Strategy to Decipher Drug Interactions. Analytical Chemistry. 2023, 95(15): 6203-6211

[4] Fanjing Guo, Genjin Lin, Liheng Dong, Kian-Kai Cheng, Lingli Deng, Xiangnan Xu, Daniel Raftery*, Jiyang Dong*. A Novel Batch Effect Correction Method for Large-Scale Metabolomics. Analytical Chemistry. 2023, 95(18): 7220-7228

[5] Jiyang Dong, Qianwen Peng, Lingli Deng, Chao Zhao*, Zongwei Cai*. Protocol for metabolic synergy analysis of multi-organs in mice using iMS2Net. STAR Protocols. 2023, 4: 102159.

[6] Jiyang Dong, Qianwen Peng, Lingli Deng, Jianjun Liu, Wei Huang, Xin Zhou, Chao Zhao*, Zongwei Cai*. iMS2Net: A Multiscale Networking Methodology to Decipher Metabolic Synergy of Organism. iScience， 2022, 25(9): 104896.

[7] Chao Zhao, Jiyang Dong, Lingli Deng, Yawen Tan, Wei Jiang, Zongwei Cai*. Molecular Network Strategy in Metabolomics and Mass Spectrometry Imaging. Current Opinion in Chemical Biology, 2022, 70:102199.

[8] Lingli Deng, Lei Ma，Kian-Kai Cheng, Xiangnan Xu, Daniel Raftery，Jiyang Dong*, Sparse PLS-Based Method for Overlapping Metabolite Set Enrichment Analysis., Journal of proteome research, 2021, 20(6)：3204-3213.

[9] Lingli Deng, Fanjing Guo, Kian-Kai Cheng, Jiangjiang Zhu, Haiwei Gu, Daniel Raftery*, Jiyang Dong*, Identifying Significant Metabolic Pathways Using Multi-Block Partial Least-Squares Analysis, Journal of Proteome Research, 2020, 19.5.1965-1974.

[10] Yueyue Liu^#, Xiangnan Xu^#, Lingli Deng, Kian-Kai Cheng, Jingjing Xu, Daniel Raftery, and Jiyang Dong*. A Novel Network Modelling for Metabolite Set Analysis: A Case Study on CRC Metabolomics. IEEE Access, 2020, 8(1):106425-106436.

[11]  Wanlan Wang, Kian-Kai Cheng, Lingli Deng, Jingjing Xu, Guiping Shen, Julian L. Griffin, Jiyang Dong*. A Clustering-based Preprocessing Method for the Elimination of Unwanted Residuals in Metabolomic Data. Metabolomics. 2017, 13(10): 1-11.

[12]  Chen Chen,  G. A. Nagana Gowda, Jiangjiang Zhu, Lingli Deng, Haiwei Gu, E. Gabriela Chiorean, Mohammad Abu Zaid, Marietta Harrison, Dabao Zhang, Min Zhang*, Daniel Raftery*, Altered metabolite levels and correlations in patients with colorectal cancer and polyps detected using seemingly unrelated regression analysis, Metabolomics, 2017, 13(125).

[13] Lingli Deng, Haiwei Gu*, Jiangjiang Zhu, G. A. Nagana Gowda, Danijel Djukovic, Elena Gabriela Chiorean, Daniel Raftery*,Combining NMR and LC/MS Using Backward Variable Elimination: Metabolomics Analysis of Colorectal Cancer, Polyps, and Healthy Controls, Analytical Chemistry, 2016，88(16): 7975-7983.

[14]  李鹏辉，邓伶莉，罗娇，李巍，宁晶，丁健桦，邬小萍*，多批次肝衰竭患者呼出气体的电喷雾萃取电离质谱检测及代谢组学数据分析，高等学校化学学报，2016，4：626-632.

[15]  刘新卓, 邓伶莉*, 王婉兰, 沈桂平, 许晶晶, 董继扬. 核磁共振代谢轮廓分析中的自适应尺度缩放新算法. 厦门大学学报(自然科学版). 2016, 55(4): 564-569.

[16]  何瑶, 郑彦婕, 邓伶莉, 许晶晶, 沈桂平, 杨万颖, 董继扬*.五常稻花香米的¹H NMR波谱分析及掺假鉴别.食品工业科技. 2016. 37 (12): 80-84.

[17] Chen Chen, Lingli Deng, Siwei Wei, G. A. Nagana Gowda, Haiwei Gu, Elena G. Chiorean, Mohammad Abu Zaid, Marietta L. Harrison, Joseph F. Pekny, Patrick J. Loehrer, Dabao Zhang, Min Zhang*, Daniel Raftery*, Exploring metabolic profile differences between colorectal polyp patients and controls using seemingly unrelated regression, Journal of Proteome Research, 2015.4.28, 14: 2492-2499.

[18]  Jiangjiang Zhu，Danijel Djukovic，Lingli Deng，Haiwei Gu，Farhan Himmati，Mohammad Abu Zaid，Elena Gabriela Chiorean，Daniel Raftery，Targetedserum metabolite profiling and sequential metabolite ratio analysis for colorectal cancer progression monitoring，Analytical and bioanalytical chemistry，2015，407：7857-7863.

[19]  Anne M. Hocking，Daniel Raftery，Ravi F. Sood，Haiwei Gu，Danijel Djukovic，Lingli Deng，Maricar Ga，Lara A. Muffley，Targeted metabolic profiling of wounds in diabetic and nondiabetic mice，Wound Repair and Regeneration，2015，23：423-434.

[20] Jiangjiang Zhu，Danijel Djukovic，Lingli Deng，Haiwei Gu，Farhan Himmati，Mohammad Abu Zaid，Elena Gabriela Chiorean，Daniel Raftery*，Colorectal cancer detection using targeted serum metabolic profiling，Journal of Proteome Research，2014，407：4120-4130.

[21]  Kwadwo Owusu-Sarfo，Vincent M Asiago，Lingli Deng，Haiwei Gu，Siwei Wei，Narasimhamurthy Shanaiah，GA Gowda，Bowei Xi，Elena G Chiorean，Daniel Raftery*，NMR-based metabolite profiling of pancreatic cancer，Current Metabolomics，2014，2：204-212.

[22]  Kian-Kai Cheng，Baek-Seok Lee，Takeshi Masuda，Takuro Ito，Kazutaka Ikeda，Akiyoshi Hirayama，Lingli Deng，Jiyang Dong，Kazuyuki Shimizu，Tomoyoshi Soga，Masaru Tomita，Bernhard O. Palsson，Martin Robert*，Global metabolic network reorganization by adaptive mutations allows fast growth of Escherichia coli on glycerol，Nature Communications，2014，5:1-9.

[23] 邓伶莉, Cheng Kian-Kai, 沈桂平, 周玲, 刘新卓, 董继扬*, 陈忠, 基于K-L散度的核磁共振波谱数据尺度缩放方法, 光谱学与光谱分析, 2014，34(10): 2868-2872.

[24] Lingli Deng, Kian-Kai Cheng, Jiyang Dong*, Julian L. Griffin, Zhong Chen, Non-negative principal component analysis for NMR-based metabolomic data analysis, Chemometrics and Intelligent Laboratory Systems, 2012，118: 51-61.